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joyce_murray2026-04-18

I recently started using Clindamycin/bpo 1.2-2.5% Gel 50gm for my acne. It's been a few weeks, and I'm seeing some improvements, but I also have some concerns about the side effects. The gel contains clindamycin, which kills acne-causing bacteria, and benzoyl peroxide, which helps reduce oil and unclog pores. I've read that it can cause some serious side effects, so I wanted to start this thread to share my experience and hear from others who have used this medication. Have any of you had severe reactions like allergic reactions or gastrointestinal issues? How did you manage them? Also, what are some tips for minimizing local irritation at the application site? Looking forward to your thoughts!

1 min read
last active 4/18/2026
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Comments (9)

J
james_bradley4/17/2026

I realized that it's helping more than before when I stopped using it for a bit and my breakouts came back in full force. I think it's important to have a skincare routine that includes this stuff, but to make sure it works for you and to consult a dermatologist if you have issues.

L
lori_allen4/17/2026

I had a mild allergic reaction when I first started using it. It was just a bit of redness and itching, but it went away after a few days. I'm glad I stuck with it because it's really helped clear up my skin.

K
katherine_green4/17/2026

I'm on my second tube now and it's done wonders for my acne. Just make sure to use it consistently and give it time to work. I notice a huge difference when I miss a day or two.

G
grace_wilson4/17/2026

Aren't benzoyl peroxide and antibiotics together a super combo for acne? Anybody tried this with another topical stuff? I'm thinking about adding a retinol cream to the mix.

K
kyle_washington4/17/2026

I had a friend who got really sick from this. He had bad diarrhea and stomach cramps — definitely consult a doctor if you start feeling off. And definitely watch out for allergic reactions. I had itchiness at first but it cleared up after a week.

L
larry_gardner4/17/2026

Be very careful with this stuff. I used it once and it dried out my skin like crazy. I had to switch to a different treatment entirely. It's a powerful medication, so start slow and see how your skin reacts.

D
david_okonkwo4/17/2026

I was worried about the side effects, but honestly, it's been fine for me. I just make sure to wash my hands after applying it and avoid getting it on my clothes. It's a bit messy, but the results are worth it. Just be careful with how much you use.

K
kenneth_jordan4/17/2026

I've been using this gel for months and it's been a game-changer for my acne. Just make sure to start with a small amount and gradually increase to avoid irritation.

E
elena_vargas4/17/2026

I've heard that benzoyl peroxide can cause discoloration on towels and clothes. Has anyone else noticed this? It's a bit inconvenient, but I guess it's a small price to pay for clearer skin.