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I was prescribed Desvenlafaxine ER Tabs 100mg for my depression. I started taking it a week ago, and I'm having mixed feelings. Some days I feel a bit better, but other days, I feel more anxious and jittery. I know it can take time for the medication to work, but I'm worried about the side effects. Has anyone else experienced this? How long did it take for you to feel the benefits, and what side effects did you have to deal with?

1 min read
last active 4/17/2026
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Comments (5)

J
joshua_morgan4/15/2026

Desvenlafaxine helped me a lot, but I had to deal with a dry mouth all the time. Chewing gum helped, but it was a pain. I figured out my dosage couldn't be changed, so it was something I just had to deal with.

K
kyle_williams4/15/2026

I've been on Desvenlafaxine for about three months now, and it's been a rollercoaster. The first few weeks were brutal with nausea and dizziness, but it got better. Give it some time, but definitely talk to your doctor if it gets worse.

S
samantha_bailey4/16/2026

I found that taking it with food helped with the nausea. I had to stick with a bland diet for a few weeks, but it got better. Be patient, but definitely talk to your doctor if it gets bad.

G
gary_cox4/16/2026

I felt like a zombie for the first two weeks. Honestly, I thought about quitting, but I stuck with it. Now, I feel a lot better, so don't give up hope. But seriously, if it gets worse, get help.

S
scott_robinson4/16/2026

Stay strong, buddy. If it gets too bad, don't feel bad about letting the doc know. Depression is hard enough without medication side effects.