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virginia_hughes2026-04-17

I was recently prescribed Pioglitazone/metformin 15-500mg Tb to help manage my type 2 diabetes. I've been taking it for about a month now, and while I've noticed some improvement in my blood sugar levels, I've also been experiencing some concerning side effects. I'm wondering if anyone else has had similar experiences. I've read about the possible side effects, but I'm still worried about some of the more serious ones like allergic reactions or lactic acidosis. Has anyone else dealt with these issues, and if so, how did you manage them? I'm also curious about the long-term effects of this medication. I've heard that it can cause weight gain and fatigue, which I'm definitely not looking forward to. I'd love to hear from anyone who has been on this medication for an extended period. How has it affected you, and what steps have you taken to mitigate any negative side effects?

1 min read
last active 4/17/2026
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Comments (6)

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beverly_spencer4/13/2026

i know this is a bit off topic but im really confused about the dosing. On the bottle, it says take one tablet in the morning and one in the evening. But my doctor said take two in the morning. Whats the correct dosage?

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stephen_sanders4/13/2026

I've been on this medication for a while and I've had no issues. I've heard that it can cause weight gain, but I've actually lost a few pounds since starting it. I've also noticed that my blood sugar levels have been more stable. It doesn't hurt to try different medications if you are not happy with the side effects.

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gary_cox4/13/2026

I had terrible stomach issues when I started taking this. Vomiting 3-5 times a day. I called my doctor and they recommended taking the pills with food. That helped a lot.

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lori_allen4/13/2026

I've been on this medication for about six months now, and while I've had some stomach issues, nothing too severe. I've also gained some weight, but that's a small price to pay for better blood sugar control. I've found that taking the medication with food helps a lot with the stomach issues. I've also been exercising regularly and watching my diet to manage the weight gain.

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hannah_washington4/13/2026

I've had a few issues with swelling and changes in eyesight. Are those common? I am a bit concerned about them. I've never experienced this before.

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sean_chen4/13/2026

I've heard that this medication can cause liver problems. I've been taking it for a while and I'm a bit worried. Has anyone else experienced any liver issues or had any liver tests done while on this medication?