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adam_owens2026-04-18

I've recently been prescribed Bortezomib to treat my multiple myeloma. I'm curious to hear from others who have used this medication. What have your experiences been like? Specifically, I'm interested in knowing about the side effects and how they were managed. Keep in mind that while Bortezomib works by blocking a specific protein complex in cancer cells called the proteasome, which helps break down old or damaged proteins, it can cause some serious side effects. Most commonly, people experience gastrointestinal symptoms, feeling dizzy, tired, or weak, difficulty sleeping, or a headache. While these are less severe, it's important to be aware of the urgent side effects that require immediate medical attention. I'm particularly worried about the risk of tumor lysis syndrome (TLS) or posterior reversible encephalopathy syndrome (PRES). I'd love to hear if anyone has had to deal with these or other severe side effects and how they coped.

1 min read
last active 4/18/2026
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Comments (10)

J
judy_berry4/15/2026

I've been on Bortezomib for about 6 months now. The first few weeks were tough with nausea and fatigue, but it's been manageable with medication. My oncologist also recommended some lifestyle changes to help with the side effects. I'd say it's been worth it, though. My cancer markers have been decreasing.

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nicholas_schmidt4/15/2026

I've had to deal with some really bad constipation. It's been a struggle, but I've been trying to manage it with diet and some over-the-counter medications.

J
joyce_ford4/15/2026

Be prepared for some serious peripheral neuropathy. It's been the worst part for me. I have to take breaks from treatment so it's frustrating.

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linda_fernandez4/15/2026

I just started Bortezomib and I'm really hoping it will work. My multiple myeloma has been really tough to treat.

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lauren_meyer4/15/2026

I was really scared of the tumor lysis syndrome risk. I had to drink a lot of water and monitor my electrolytes closely, but I didn't have any major issues.

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ashley_alvarez4/15/2026

Be careful with the injection site. I had some bad irritation and had to use ice packs to help reduce inflammation.

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grace_wilson4/15/2026

Stay strong, everyone. We're all in this together.

H
hannah_alvarez4/15/2026

I have a friend who took Bortezomib and had to stop due to severe PRES. It's scary stuff. If you start noticing any neurological symptoms, don't wait, get to the ER.

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nancy_santos4/15/2026

I've heard that some people have trouble with blood pressure changes. Has anyone had to deal with that?

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robert_stephens4/15/2026

I've actually had a pretty good experience with Bortezomib. I had some fatigue and nausea, but nothing I couldn't handle. My doctor put me on a preventative anti-nausea medication to help with it. Make sure you're communicating openly with your doctor about any side effects you're experiencing. They can often provide solutions to help manage them. Don't just suffer through it.