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justin_vargas2026-04-18

Naloxone is a lifesaving medication that can reverse the effects of an opioid overdose. It works by blocking the effects of opioids on the brain, helping the person to breathe again and potentially saving their life. It is available as a nasal spray for easier administration. This thread discusses: What to do in an emergency, the proper administration of this drug, and possible side effects, positive and negative. Also: what can go wrong? Add your experiences in the comments.

1 min read
last active 4/18/2026
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Comments (5)

J
james_morrison4/13/2026

I had to use Naloxone once on a friend who overdosed. I was so nervous, but the spray was easy to use. They came to almost immediately. Best $35 I ever spent. Note: if they're not breathing and you can't get them to respond, call 911 ASAP. If they're breathing, use Naloxone and monitor them. If they start seizing, call 911.

P
pamela_nelson4/13/2026

I've heard that Naloxone can cause withdrawal symptoms in the person who overdosed. Is that true? What should I expect? Yes, they may show signs of severe withdrawal. This can look like agitation, sweating, nausea, vomiting, diarrhea, fever, and intense cravings. This will be very uncomfortable for them.

T
teresa_henry4/13/2026

I carry Naloxone with me everywhere I go, never know when you might need it. Make sure to read the instructions before you need it, practice with an empty spray when you can.

K
kenneth_jordan4/13/2026

I had a really bad reaction to Naloxone once. I had a seizure and my blood pressure dropped dangerously low. Be aware of the risks.

J
jonathan_hamilton4/13/2026

Does anyone know if Naloxone can be used on pets? My dog got into some pills and I'm worried.