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wayne_silva2026-04-18

I've been prescribed Otrexup 22.5/0.4ml Inj, 0.4ml for my rheumatoid arthritis, and I'm a bit nervous about the potential side effects. The medication is supposed to help reduce inflammation and slow down the progression of the disease, but the list of possible side effects is quite long and alarming. Has anyone else had experience with this medication? I'm particularly concerned about the severe side effects like allergic reactions, bleeding, and issues with vital organs. How common are these, and what should I expect? Also, I've heard that it can be given as a shot, but are there any tips for making the injections less painful? I appreciate any insights from those who have gone through a similar experience.

1 min read
last active 4/18/2026
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Comments (6)

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grace_wilson4/15/2026

I've been on Otrexup for a few years now, and it's been a game-changer for my psoriasis. The side effects are manageable, and the relief from the symptoms is worth it.

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kyle_washington4/15/2026

I've been on Otrexup for a year now and the only side effects I've experienced are some mild dizziness and hair loss. I'm on the lower dosage though, so maybe that helps.

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christian_cox4/15/2026

I've had a severe allergic reaction to a different medication before, so I'm really nervous about trying Otrexup. But my doctor says the benefits are worth the risk. Anyone else had this issue?

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ashley_alvarez4/15/2026

I've been on Otrexup for a few months now, and while I've had some hair loss, it's nothing compared to the relief I get from the arthritis pain. Definitely worth it for me, but everyone's experience is different.

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elena_vargas4/15/2026

I had an awful experience with this medication. Ended up with severe stomach pain and ended up in the hospital with pancreatitis. It was terrifying. Make sure you're really keeping an eye out for those side effects!

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hannah_alvarez4/15/2026

I'm pretty sure I'm going to try this medication since it works for psoriasis which is what I have. I'm a bit nervous but I really want to try anything that will help me. The side effects are scary but I am hoping they are rare. Has anyone had any other issues with this medication that are not listed?