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I've been prescribed Promethazine 25mg Suppositories for motion sickness and I'm not sure what to expect. I've heard it can help a lot, but I'm a bit hesitant about the suppository form. Plus, I'm worried about the potential side effects, especially the more serious ones like allergic reactions or neurological problems. Has anyone else tried this? What was your experience like? I'm particularly interested in hearing about any unusual side effects or tips for making the experience more comfortable.

1 min read
last active 4/18/2026
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Comments (4)

J
judith_moreno4/13/2026

If you're worried about side effects, maybe talk to your doctor about starting with a lower dose and seeing how you react. It's always better to be safe.

R
robert_stephens4/13/2026

I had to use these for a long car ride and they worked like a charm. I didn't experience any major side effects, just a bit of drowsiness. Definitely worth it if you're really struggling with motion sickness.

S
scott_robinson4/13/2026

I've heard that Neurologic Malignant Syndrome has low incidence but high mortality. If you have to take these, hope for the best, prepare for the worst by knowing the signs.

A
amber_sherman4/13/2026

I actually had a really bad experience with Promethazine. I ended up with some neurological issues like trouble controlling my movements and had to go to the ER. It's scary stuff, so be cautious and keep an eye out for any weird symptoms.