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priya_sharma2026-04-18

I just got my first Zilretta injection in my knee to help with osteoarthritis pain. I'm a bit nervous about the potential side effects, especially the urgent ones. Has anyone else here had this injection? How did it go for you? I'm hoping it helps with the pain, but I'm also concerned about the potential for serious side effects. Any tips or advice on how to manage this would be appreciated! The long list of side effects on the FDA website is somewhat alarming. Has anyone else had trouble with any of the less severe side effects, like trouble sleeping? I want to make an informed decision about this.

1 min read
last active 4/18/2026
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Comments (7)

M
martha_nichols4/16/2026

I had some muscle weakness after my injection, but it went away after a couple of days. Just keep an eye on any unusual symptoms and talk to your doctor.

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pamela_nelson4/16/2026

I got the injection last month and it was worth it. I had some minor swelling at the injection site initially, but nothing I couldn't handle. The pain relief was noticeable after a few days, and it lasted for several weeks.

T
timothy_thompson4/16/2026

My mom had this injection and it helped her so much, really glad she tried it! But my friend had issues with it as well. It's all about the luck, I think.

C
christian_cox4/16/2026

I've heard people talk about Cushing's syndrome as a side effect. Not sure what that is, anyone know more about it? If you're not sure, it sounds scary, but I think the side effects are rare.

C
christopher_hansen4/16/2026

I'm really worried about the potential for high blood sugar. Is there anything I can do to monitor this more closely? Anyone have any experience with that?

S
sean_wallace4/16/2026

I had a really bad experience with Zilretta. I ended up with a severe allergic reaction and had to go to the ER. It was terrifying, and I'm not sure I would try it again.

J
joe_james4/16/2026

I would recommend talking to your doctor about other options if Zilretta doesn't work well for you. There are other pain management options out there, but if you can tolerate Zilretta, it's worth a try.