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james_bradley2026-04-18

I’ve been struggling with depression and anxiety for a while now, and my doctor prescribed Perphenazine/amitriptyline 2-25 Tab. It’s a combo of amitriptyline (an antidepressant) and perphenazine (an antipsychotic). I’m wondering if anyone else has tried this and had any positive or negative experiences. The side effects list is a bit scary, especially the severe ones like allergic reactions and liver problems. Has anyone experienced these, or is it mostly mild stuff like dizziness and dry mouth? How does it affect daily life? Any tips on managing the side effects would be greatly appreciated.

1 min read
last active 4/18/2026
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Comments (10)

P
pamela_nelson4/15/2026

Depression sucks and anything that helps, right? But this one is a double-edged sword. Stick it out for a few weeks and talk openly to your doctor. That’s how I managed my side effects.

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nancy_herrera4/15/2026

I had a really bad reaction to the perphenazine part. I developed some weird muscle movements and my doctor said it was tardive dyskinesia. Scary stuff, I had to stop taking it immediately.

J
joyce_murray4/16/2026

You gotta weigh the pros and cons. It’s helped a lot with my mood swings but the constant dry mouth is annoying. Drink lots of water to counteract that.

R
richard_wagner4/16/2026

Be careful with this one. I ended up in the ER with severe stomach pain. Turns out it was a rare but serious side effect. Not worth the risk for me.

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linda_fernandez4/16/2026

I feel like a zombie sometimes because of the drowsiness, but otherwise, it's been helping. Just try to take it at night, so the sleepiness isn’t a big issue.

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peter_daniels4/16/2026

I’ve heard good things about the combo. Just make sure to talk to your doctor regularly and keep an eye out for any serious side effects, like the neurological symptoms.

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patrick_dunn4/16/2026

I've been on this medication for a few months. Side effects were rough initially, but now it's manageable. Make sure to stay hydrated to avoid the dryness!

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nancy_santos4/16/2026

I had some trouble with dizziness and dry mouth, but nothing too bad. It took a few weeks to kick in, but now I feel more balanced. It’s been great for my anxiety, and the depression symptoms have gotten way better too. I still get some headaches but it's nothing I can't handle with ibuprofen.

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judith_moreno4/16/2026

I’m considering this medication for my anxiety. What’s the worst side effect you’ve had? I’m nervous about the Tardive Dyskinesia part.

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kyle_williams4/16/2026

I’ve been on this for a few months and it’s been a game-changer. The side effects were tough at first, but my doctor adjusted the dose and now I’m feeling much better. Definitely worth sticking it out if you can.

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