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randy_ramirez2026-04-18

I've been dealing with anal fissures for a while now and my doctor prescribed Nitroglycerin 0.4% Ointment. I'm a bit anxious about trying it because of the potential side effects, especially the severe ones. Has anyone else used this medication? What was your experience like? Did you encounter any of the listed side effects? How long did it take for the fissure to heal? I want to know how well this actually works and if it's worth dealing with any discomfort or side effects. I've also heard that the dosage can affect how well it works, so if you have any tips on how to apply it, that would be great.

1 min read
last active 4/18/2026
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Comments (8)

M
martha_nichols4/16/2026

This stuff really works. Just be patient and follow the instructions closely.

S
sean_wallace4/16/2026

I've been using it for a couple of weeks now, and it's been a game-changer. The headaches were pretty bad at first, but they've gotten better. Just make sure to apply it really carefully, as directed. No serious side effects so far, fingers crossed.

J
joshua_morgan4/16/2026

I had a bad reaction with severe nausea and I’m going to get a second opinion from another doctor.

K
kyle_washington4/16/2026

Be aware: The ointment can cause your heart to race. I didn’t know this and it freaked me out.

N
nancy_herrera4/16/2026

I've had great success with this ointment. It took about a month for my fissure to heal completely. The headaches were intense at first, but they subsided after a week. Definitely worth it to me, but everyone is different.

M
martha_lane4/16/2026

It was a bit awkward applying the ointment at first, but you get used to it. Just make sure to wash your hands thoroughly afterward. The fissure healed pretty quickly, so it was worth it for me.

M
matthew_dixon4/16/2026

I think it works well, but some people really struggle with the headaches. My doctor told me to take an ibuprofen 30 min before applying. I can handle this but your milage may vary.

W
wayne_silva4/16/2026

Be careful with this stuff. I reacted really badly to it, had the worst dizziness ever. Ended up in the ER. Itchiness around the anus went away though