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I've been using Zyclara 3.75% Cream to treat some stubborn warts on my face and neck. The cream itself is easy to apply, but I've been experiencing some pretty severe side effects. I'm wondering if anyone else has had a similar experience and what they did to manage it. The box says to expect some redness and itching, but I've also been feeling really weak and getting these massive flu-like symptoms. My doctor told me that these symptoms can happen, but that they are rare. Is it safe to continue using the cream, or should I go back to the doctor? I'm nervous to just take off a week without talking to the doctor.

1 min read
last active 4/17/2026
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Comments (4)

R
ralph_andrews4/15/2026

I had a really bad reaction to Zyclara. I got hives and swelling all over my face. I had to go to the emergency room. They gave me some kind of allergy shot and told me to avoid it at all costs. I'm so glad I did not try and ride it out.

S
samantha_bailey4/15/2026

I've been using Zyclara for a few weeks and it's been great for my warts, but I've also been getting really tired and weak. Is this normal?

K
kenneth_jordan4/15/2026

I've been using Zyclara for a few weeks and it's been great for my warts, but I've also been getting really tired and weak. Is this normal?

K
kathleen_gray4/15/2026

I had terrible pain and swollenness! The allergy did go away, but it returned even worse. The doc told me to stop using the cream.